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Cryovial Filler

3P innovation has developed the world's first true GMP automated cryovial filling platform, helping to drive quality in the cell and gene industry.

Incorporating our existing fill-finish technology, the aseptic and cGMP compliant platform provides reliable and repeatable liquid filling. The technology is incorporated within a BioSafety Cabinet and provides 100% fill weight verification together with full 21CFR Part11 compliance via the recipe manager on the HMI.

Benefits

  • Maximise cell yield through minimised hold-up volume, intelligent closed loop filling with 100% weight verification and zero-loss priming sequence.
  • Automated cryovial placement into racks for fast transfer to your existing controlled rate freezer (CRF).
  • Accurate and repeatable filling with a high precision low-shear peristaltic pump.
  • Ensure security of your samples with precision control of cap tightening torque.
  • Highest standards of hygienic design, including ‘first air’ principles and minimised vial open time.
  • Compact footprint - integrated within a 5' BSC. Optional integration with other BSCs or isolators - contact us to discuss
  • Supports the majority of cryovials, both internally and externally threaded variants with simple change parts between variants.  

 

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Vials are pre-loaded onto a tray prior to placing on the filling platform.  During operation, cryovials are transferred from the tray to the filling module where each vial is de-capped, filled, and subsequently recapped before being transferred back to the tray in its original position. Batch data and processes can be controlled and monitored by the HMI control panel.

cryovial diagram